Frederick G Hayden Selected Research

Oseltamivir (Tamiflu)

10/2021	Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group.
12/2020	Phase 2a, open-label, dose-escalating, multi-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza.
10/2020	Early treatment with baloxavir marboxil in high-risk adolescent and adult outpatients with uncomplicated influenza (CAPSTONE-2): a randomised, placebo-controlled, phase 3 trial.
1/2020	Critical care management of adults with community-acquired severe respiratory viral infection.
1/2020	Comparative Effectiveness of Combined Favipiravir and Oseltamivir Therapy Versus Oseltamivir Monotherapy in Critically Ill Patients With Influenza Virus Infection.
1/2019	Influenza virus polymerase inhibitors in clinical development.
1/2018	Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.
6/2013	Oseltamivir resistance during treatment of H7N9 infection.
1/2007	Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials.
11/2006	Antiviral management of seasonal and pandemic influenza.

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Frederick G Hayden Research Topics

Disease

61	Human Influenza (Influenza) 11/2022 - 03/2002
28	Infections 11/2022 - 02/2002
10	COVID-19 07/2021 - 01/2020
10	Coronavirus Infections 10/2020 - 11/2013
9	Critical Illness (Critically Ill) 12/2020 - 12/2014
6	Pneumonia (Pneumonitis) 05/2020 - 05/2002
4	Virus Diseases (Viral Diseases) 10/2021 - 11/2013
4	Communicable Diseases (Infectious Diseases) 07/2021 - 04/2009
4	Nausea 10/2020 - 03/2002
3	Respiratory Insufficiency (Respiratory Failure) 01/2020 - 10/2017
2	Diarrhea 04/2021 - 06/2003
2	Hypertension (High Blood Pressure) 10/2020 - 10/2020
2	Ebola Hemorrhagic Fever 01/2018 - 01/2017
2	Respiratory Syncytial Virus Infections 03/2015 - 11/2008
2	Common Cold 01/2009 - 11/2005
1	Fever (Fevers) 11/2022
1	Sepsis (Septicemia) 01/2021
1	Viral Pneumonia 04/2019
1	Herpesviridae Infections (Herpesvirus Infection) 01/2018
1	Respiratory Tract Infections (Respiratory Tract Infection) 11/2014
1	Severe Acute Respiratory Syndrome 11/2014
1	Lung Injury 11/2011
1	Orthomyxoviridae Infections 08/2009
1	Guillain-Barre Syndrome 08/2009
1	Sneezing 10/2006
1	Influenza in Birds (Avian Flu) 04/2006
1	Weight Loss (Weight Reduction) 03/2006

Drug/Important Bio-Agent (IBA)

37	Antiviral Agents (Antivirals)IBA 11/2022 - 03/2002
19	Oseltamivir (Tamiflu)FDA Link 10/2021 - 03/2002
18	Neuraminidase (Sialidase)IBA 10/2021 - 03/2002
10	VaccinesIBA 01/2022 - 11/2004
9	Zanamivir (Relenza)FDA Link 10/2021 - 03/2002
9	baloxavirIBA 10/2021 - 01/2018
8	Pharmaceutical PreparationsIBA 11/2022 - 01/2005
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2002
4	favipiravirIBA 11/2022 - 01/2019
4	Ritonavir (Norvir)FDA Link 10/2020 - 01/2018
4	Lopinavir FDA Link 10/2020 - 01/2018
4	EndonucleasesIBA 10/2020 - 01/2018
4	Influenza Vaccines (Influenza Vaccine)FDA Link 08/2009 - 04/2007
4	Hemagglutinins (Hemagglutinin)IBA 11/2008 - 12/2002
4	Rimantadine FDA LinkGeneric 11/2006 - 03/2002
3	remdesivirIBA 01/2021 - 01/2020
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 01/2018
3	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2020 - 05/2002
3	Oxygen (Dioxygen)IBA 01/2020 - 10/2017
3	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2018
3	Immunologic Factors (Immunomodulators)IBA 12/2014 - 08/2006
3	Amantadine (Aman)FDA LinkGeneric 11/2006 - 03/2002
3	pleconarilIBA 11/2005 - 03/2002
2	TabletsIBA 11/2022 - 03/2002
2	InterferonsIBA 01/2020 - 01/2020
2	MacrolidesIBA 01/2020 - 04/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 11/2014 - 11/2006
2	Ion Channels (Ion Channel)IBA 11/2006 - 11/2004
2	peramivirIBA 08/2006 - 01/2005
2	EnzymesIBA 07/2006 - 02/2002
2	AntigensIBA 02/2005 - 03/2002
2	Immunoglobulin E (IgE)IBA 08/2004 - 05/2003
1	Viral RNAIBA 11/2022
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2021
1	Interferon beta-1b (Betaseron)FDA Link 10/2020
1	Angiotensin Receptor AntagonistsIBA 10/2020
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2020
1	Antihypertensive Agents (Antihypertensives)IBA 10/2020
1	Transaminases (Aminotransferases)IBA 10/2020
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020
1	Sirolimus (Rapamycin)FDA Link 01/2020
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2020
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2020
1	Ribavirin (Virazole)FDA LinkGeneric 01/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019
1	pimodivirIBA 01/2019
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2019
1	Anti-Infective Agents (Microbicides)IBA 11/2014
1	AntibodiesIBA 01/2013
1	Drug CombinationsIBA 01/2013
1	Conjugated Linoleic AcidsIBA 01/2009
1	Respiratory Syncytial Virus VaccinesIBA 11/2008
1	Histamine (Histamine Dihydrochloride)FDA Link 10/2006
1	Protons (Proton)IBA 09/2006
1	Inosine FDA Link 08/2006
1	methyl inosine monophosphate (MIMP)IBA 08/2006
1	oplunofuspIBA 04/2006
1	Sialic AcidsIBA 04/2006
1	Recombinant Fusion ProteinsIBA 04/2006
1	sialic acid receptorIBA 04/2006
1	A-322278IBA 03/2006

Therapy/Procedure

24	Therapeutics 07/2021 - 03/2006
7	Chemoprevention 01/2019 - 11/2004
2	Secondary Prevention 10/2020 - 07/2007
2	Noninvasive Ventilation 01/2020 - 01/2019
2	Artificial Respiration (Mechanical Ventilation) 01/2019 - 10/2017
2	Length of Stay 01/2019 - 05/2002
2	Investigational Therapies (Experimental Therapy) 01/2017 - 05/2002
2	Drug Therapy (Chemotherapy) 07/2007 - 09/2006
1	Critical Care (Surgical Intensive Care) 01/2020
1	Renal Replacement Therapy (Therapies, Renal Replacement) 10/2017
1	Extracorporeal Membrane Oxygenation 10/2017
1	Immunotherapy 01/2016